The protein corona and its effects on nanoparticle-based drug delivery systems

H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …

Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery

W Kim, NK Ly, Y He, Y Li, Z Yuan, Y Yeo - Advanced drug delivery reviews, 2023 - Elsevier
For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

The role of protein corona on nanodrugs for organ-targeting and its prospects of application

S Wang, J Zhang, H Zhou, YC Lu, X Jin, L Luo… - Journal of Controlled …, 2023 - Elsevier
Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …

The interaction between nanoparticles-protein corona complex and cells and its toxic effect on cells

N Liu, M Tang, J Ding - Chemosphere, 2020 - Elsevier
Once nanoparticles (NPs) contact with the biological fluids, the proteins immediately adsorb
onto their surface, forming a layer called protein corona (PC), which bestows the biological …

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

S Khan, M Sharifi, JP Gleghorn, MMN Babadaei… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (NPs) have been used in numerous applications as anticancer, antibacterial
and antioxidant agents. Artificial engineering of protein interactions with NPs in biological …

Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models

S Liu, X Wu, W Gu, J Yu, B Wu - Chemosphere, 2020 - Elsevier
The digestive tract is an important target organ for microplastics (MPs). However, little is
known about the effects of digestive treatment on the intestinal toxicity of MPs. In this study …

[HTML][HTML] Surface charge influences protein corona, cell uptake and biological effects of carbon dots

Y Arezki, F Delalande, C Schaeffer-Reiss, S Cianférani… - Nanoscale, 2022 - pubs.rsc.org
Carbon dots are emerging nanoparticles (NPs) with tremendous applications, especially in
the biomedical field. Herein is reported the first quantitative proteomic analysis of the protein …

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications …

V Agrahari, PA Burnouf, T Burnouf… - Advanced Drug Delivery …, 2019 - Elsevier
Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …

[HTML][HTML] Protein adsorption: a feasible method for nanoparticle functionalization?

R Cagliani, F Gatto, G Bardi - Materials, 2019 - mdpi.com
Nanomaterials are now well-established components of many sectors of science and
technology. Their sizes, structures, and chemical properties allow for the exploration of a …

Protein corona, influence on drug delivery system and its improvement strategy: A review

F Guo, S Luo, L Wang, M Wang, F Wu, Y Wang… - International Journal of …, 2023 - Elsevier
Nano drug delivery systems offer several benefits, including enhancing drug solubility,
regulating drug release, prolonging drug circulation time, and minimized toxicity and side …