We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …

Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

It is widely accepted that unrepaired or misrepaired DNA double strand breaks (DSBs) lead
to the formation of chromosome aberrations. DSBs induced in the DNA of higher eukaryotes …

The objective of this state of the art paper is to review the mechanisms of induction, the fate,
the methodology, the sensitivity/specificity and predictivity of two major cytogenetic …

DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …

Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on
modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a primary …

L'histone H2AX phosphorylée (H2AX γ) est essentielle pour la reconnaissance et/ou la
réparation efficace des cassures double brin de l'ADN. De nombreuses molécules (souvent …

Eukaryotes come in many shapes and sizes, yet one thing that they all seem to share is a
decline in vitality and health over time—a process known as ageing. If there are conserved …