Abstract Deficiency of ADA2 (DADA2) is the first molecularly described monogenic vasculitis
syndrome. DADA2 is caused by biallelic hypomorphic mutations in the ADA2 gene that …

Human adenosine deaminase 1 deficiency was described in the 1970s to cause severe
combined immunodeficiency. The residual adenosine deaminase activity in these patients …

Adenosine is a potent endogenous regulator of inflammation and tissue repair. Adenosine,
which is released from injured and hypoxic tissue or in response to toxins and medications …

Drug side effects levy a massive cost on society through drug failures, morbidity, and
mortality cases every year, and their early detection is critically important. Here, we describe …

Abstract Adenosine deaminase 2 deficiency (DADA2) is a rare inherited disorder that is
caused by autosomal recessive mutations in the ADA2 gene. Clinical manifestations include …

Mechanisms linking immune sensing of DNA danger signals in the extracellular
environment to innate pathways in the cytosol are poorly understood. Here, we identify a …

AIM: To examine the possible effects of honey supplementation on hepatic damage due to
obstruction of the common bile duct in an experimental rat model. METHODS: The study was …

Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which
monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell …

Background and purpose The evaluation of adenosine deaminase (ADA) activity in sera of
patients with hepatitis should be considered a useful tool in the monitoring of their clinical …

The deficiency of adenosine deaminase 2 (DADA2) has recently been defined as a
monogenetic autosomal recessive autoinflammatory disease. DADA2 is mainly …