Brucella spp. are intracellular gram-negative bacteria that include a number of virulent
species that cause chronic infections in a variety of mammalian hosts. Human infections are …

Brucella can parasitize within human antigen-presenting cells modifying phagocytosis,
phagolysosome fusion, antigen presentation, cytokine secretion, and apoptosis. Subversion …

Resistance to intracellular bacterial pathogens such as Brucella spp. relies on cell-mediated
immunity, which involves activation of the bactericidal mechanisms of antigen-presenting …

Brucellosis, caused by the intracellular pathogens Brucella, is one of the major zoonotic
infections. Considering the economic burden, its prevalence has been a health concern …

Brucella spp. infection results in compromised Type1 (Th1) cellular immune response.
Several reports have described an immunomodulatory function for Brucella major outer …

Human brucellosis is a worldwide zoonotic infectious disease which is caused by
intracellular bacteria belonging to the genus Brucella. Based on murine studies it has been …

Abstract Development of a Chlamydia trachomatis vaccine has been a formidable task partly
because of an ineffective delivery system. Our laboratory has generated a recombinant …

Dendritic cells produce cytokines that regulate the class of the adaptive immune response.
Microbial recognition is mediated, at least in part, by pattern recognition receptors such as …

Our recent study suggested the reverse relationship between the production of interleukin‐
10 (IL‐10) and IL‐12 in dendritic cells (DCs) activated by lipopolysaccharide (LPS) or LPS …

Background: It seems that polymorphism in the regulatory areas of cytokine genes affects
the cytokine production capacity and may play a role in the development of infectious …