Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms

JM Kwiecinski, AR Horswill - Current opinion in microbiology, 2020 - Elsevier
Highlights•Phagocytes play both protective and detrimental roles in containing bloodstream
S. aureus.•S. aureus hijacks the host coagulation system and uses it to bind host …

Virulence factors in coagulase-negative staphylococci

A França, V Gaio, N Lopes, LDR Melo - Pathogens, 2021 - mdpi.com
Coagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-
associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S …

Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant Staphylococcus aureus: a genomic epidemiology analysis

F Coll, KE Raven, GM Knight, B Blane… - The Lancet …, 2020 - thelancet.com
Background Whole-genome sequencing (WGS) can be used in genomic epidemiology
investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted …

MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation

S Dyzenhaus, MJ Sullivan, B Alburquerque, D Boff… - Cell host & …, 2023 - cell.com
The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-
MRSA) USA300 lineage has recently become a leading cause of hospital-associated …

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

L Tuchscherr, B Löffler, RA Proctor - Frontiers in Microbiology, 2020 - frontiersin.org
Staphylococcus aureus is able to survive within host cells by switching its phenotype to the
small-colony variant (SCV) phenotype. The emergence of SCVs is associated with the …

Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle

X Ding, C Robbe-Masselot, X Fu, R Léonard… - Nature …, 2023 - nature.com
Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway
environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is …

Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations

A Both, J Huang, M Qi, C Lausmann… - PLoS …, 2021 - journals.plos.org
S. epidermidis is a substantial component of the human skin microbiota, but also one of the
major causes of nosocomial infection in the context of implanted medical devices. We here …

Bacterial–fungal interactions promote parallel evolution of global transcriptional regulators in a widespread Staphylococcus species

CM Cosetta, B Niccum, N Kamkari, M Dente… - The ISME …, 2023 - academic.oup.com
Experimental studies of microbial evolution have largely focused on monocultures of model
organisms, but most microbes live in communities where interactions with other species may …