Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

The human immunodeficiency virus type 1 (HIV‐1) is the major etiological agent responsible
for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …

RNAs are underexploited targets for small molecule drugs or chemical probes of function.
This may be due, in part, to a fundamental lack of understanding of the types of small …

Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

As the carrier of genetic information, the DNA double helix interacts with many natural
ligands during the cell cycle, and is amenable to such intervention in diseases such as …

Covering: 1980 to 2011 Major groove recognition of DNA by proteins utilizes the variation in
hydrogen bond donor/acceptor content that makes DNA base-pairs distinguishable from one …

Diversification of RNA-targeted scaffolds offers great promise in the search for selective
ligands of therapeutically relevant RNA such as HIV-1 TAR. We herein report the …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Despite their clinical importance, saving numerous human lifes, over-and mis-uses of
antibiotics have created a strong selective pressure on bacteria, which induces the …