Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

The burden of heart failure (HF), developing after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

Improvements in early interventions after acute myocardial infarction (AMI), notably, the
increased use of timely reperfusion therapy, have increased survival dramatically in recent …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Tissue repair after injury is a complex, metabolically demanding process. Depending on the
tissue's regenerative capacity and the quality of the inflammatory response, the outcome is …

Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …