Rationale There is increasing interest in antipsychotics intended to manage positive
symptoms via D 2 receptor blockade and improve negative symptoms and cognitive deficits …

Objective To review the evidence that agents which preferentially affect serotonin (5-HT)
attenuate the ability of N-methyl-D-aspartate (NMDA) receptor non-competitive antagonists …

The psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol, produces in humans
subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous …

To investigate the possible long-term consequences of gestational exposure to
cannabinoids on cognitive functions, pregnant rats were administered with the CB1 receptor …

In previous studies, we demonstrated that tandospirone, a serotonin-5-HT1A partial agonist,
added to ongoing treatment with small to moderate doses of typical antipsychotic drugs …

Background The bidirectional communication between neurons and microglia is
fundamental for the homeostasis and biological function of the central nervous system …

We have previously reported that lurasidone, a novel atypical antipsychotic with potent
serotonin 5-HT7 antagonist and 5-HT1A partial agonist activities, is superior to other …

Recently, a novel paradigm has been designed to assess social investigative behaviour in
pairs of Sprague–Dawley rats, which involves physical separation whilst ensuring they are …

Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa.
This study investigated the effect of spinosin on cholinergic blockade-induced memory …

Abstract Rationale Atypical antipsychotic drugs (APDs), many of which are direct or indirect
serotonin (5-HT) 1A agonists, and tandospirone, a 5-HT 1A partial agonist, have been …