Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline–Update 2022

ML Gauci, C Aristei, JC Becker, A Blom… - European Journal of …, 2022 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all
cutaneous malignancies. It is found predominantly in white populations and risk factors …

Molecular pathogenesis of Merkel cell carcinoma

JA DeCaprio - Annual Review of Pathology: Mechanisms of …, 2021 - annualreviews.org
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with
two distinct etiologies. Clonal integration of Merkel cell polyomavirus DNA into the tumor …

[HTML][HTML] APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

EK Law, R Levin-Klein, MC Jarvis, H Kim… - Journal of Experimental …, 2020 - rupress.org
The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second
largest source of mutation in cancer. This mutational process may be a causal driver or …

Epigenetic dysregulations in merkel cell polyomavirus-driven merkel cell carcinoma

JC Rotondo, C Mazziotta, C Lanzillotti… - International Journal of …, 2021 - mdpi.com
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is
the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the …

The role of histone post-translational modifications in merkel cell carcinoma

C Mazziotta, C Lanzillotti, R Gafà, A Touzé… - Frontiers in …, 2022 - frontiersin.org
Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin
cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA …

Virus-positive Merkel cell carcinoma is an independent prognostic group with distinct predictive biomarkers

KL Harms, L Zhao, B Johnson, X Wang… - Clinical Cancer …, 2021 - AACR
Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine
carcinoma that can be divided into two classes: virus-positive (VP) MCC, associated with …

[HTML][HTML] Merkel cell carcinoma

JC Becker - Annals of Oncology, 2010 - Elsevier
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin.
The incidence of this rare tumor is increasing rapidly; the American Cancer Society …

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma

PC Lee, S Klaeger, PM Le, K Korthauer… - The Journal of …, 2022 - Am Soc Clin Investig
Cancers avoid immune surveillance through an array of mechanisms, including perturbation
of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I …

Merkel cell polyomavirus: oncogenesis in a stable genome

MM Ahmed, CH Cushman, JA DeCaprio - Viruses, 2021 - mdpi.com
Merkel cell polyomavirus (MCV) is the causative agent for the majority of Merkel cell
carcinoma (MCC) cases. Polyomavirus-associated MCC (MCCP) is characterized by the …

Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1‐deficient skin carcinoma

T Kervarrec, E Frouin, C Collin, A Tallet… - …, 2023 - Wiley Online Library
Aims Recently, YAP1 fusion genes have been demonstrated in eccrine poroma and
porocarcinoma, and the diagnostic use of YAP1 immunohistochemistry has been …