Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

SH Siddiqi, FL Schaper, A Horn, J Hsu… - Nature human …, 2021 - nature.com
Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …

The impact of modern-day neuroimaging on the field of deep brain stimulation

A Horn - Current opinion in neurology, 2019 - journals.lww.com
The impact of modern-day neuroimaging on the field of deep b... : Current Opinion in
Neurology The impact of modern-day neuroimaging on the field of deep brain stimulation …

Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease

TA Dembek, J Roediger, A Horn, P Reker… - Annals of …, 2019 - Wiley Online Library
Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in
the subthalamic nucleus (STN) can predict motor improvement in Parkinson disease (PD) …

[HTML][HTML] Neuroimaging and electrophysiology meet invasive neurostimulation for causal interrogations and modulations of brain states

G Gonzalez-Escamilla, M Muthuraman, D Ciolac… - Neuroimage, 2020 - Elsevier
Deep brain stimulation (DBS) has developed over the last twenty years into a highly effective
evidenced-based treatment option for neuropsychiatric disorders. Moreover, it has become a …

Non-motor outcomes depend on location of neurostimulation in Parkinson's disease

JN Petry-Schmelzer, M Krause, TA Dembek, A Horn… - Brain, 2019 - academic.oup.com
Deep brain stimulation of the subthalamic nucleus is an effective and established therapy for
patients with advanced Parkinson's disease improving quality of life, motor symptoms and …

Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation

CP Mosher, AN Mamelak, M Malekmohammadi… - Neuron, 2021 - cell.com
The subthalamic nucleus (STN) supports action selection by inhibiting all motor programs
except the desired one. Recent evidence suggests that STN can also cancel an already …

Zona incerta subpopulations differentially encode and modulate anxiety

Z Li, G Rizzi, KR Tan - Science advances, 2021 - science.org
Despite recent clinical observations linking the zona incerta (ZI) to anxiety, little is known
about whether and how the ZI processes anxiety. Here, we subject mice to anxious …

[HTML][HTML] Sweetspot mapping in deep brain stimulation: strengths and limitations of current approaches

TA Dembek, JC Baldermann… - … : Technology at the …, 2022 - Elsevier
Objectives Open questions remain regarding the optimal target, or sweetspot, for deep brain
stimulation (DBS) in, for example, Parkinson's disease. Previous studies introduced different …

Stimulation sweet spot in subthalamic deep brain stimulation–myth or reality? A critical review of literature

A de Roquemaurel, T Wirth, N Vijiaratnam… - Stereotactic and …, 2021 - karger.com
Introduction: While deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been
extensively used for more than 20 years in Parkinson's disease (PD), the optimal area of …

Unilateral stimulation of subthalamic nucleus does not affect inhibitory control

C Mancini, N Modugno, M Santilli, L Pavone… - Frontiers in …, 2019 - frontiersin.org
Despite the relevance of inhibitory control in shaping our behavior its neural substrates are
still hotly debated. In this regard, it has been suggested that inhibitory control relies upon a …