Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell
metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some …

Drug resistance is one of the significant clinical burden in renal cell carcinoma (RCC). The
development of drug resistance is attributed to many factors, including impairment of …

Nrf1 (encoded by Nfe2l1) and Nrf2 (encoded by Nfe2l2), as two key members of the CNC-
bZIP transcription factor, exhibit significant functional differences in their pathophysiology …

The unique hypoxic inflammatory microenvironment observed in the spinal cord following
spinal cord injury (SCI) limits the survival and efficacy of transplanted bone mesenchymal …

Emerging single-cell technologies create new opportunities for unraveling tumor
heterogeneity. However, the development of high-content phenotyping platform is still at its …

Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM
represents> 50% of primary tumors of the nervous system and~ 20% of intracranial …

The majority of modern treatment methods for malignant brain tumors are not sufficiently
effective, with a median survival time varying between 9 and 14 months. Metastatic and …

Hypoxia is a universal characteristic of solid tumor and involving cancer metastasis via
epithelial‐mesenchymal transition (EMT). Nobiletin (3′, 4′, 5, 6, 7, 8 …

Aim When peritoneal fibrosis (PF) causes ultrafiltration failure in peritoneal dialysis (PD)
patients, PD has to be discontinued. Currently, there is no effective way to relieve PF. In this …

Hypoxia induces vigorous growth and a higher malignant phenotype in solid tumors.
Hyperoxic treatment using hyperbaric oxygen (HBO) has previously been shown as a highly …