Cancer is a complex multifactorial disease that results from alterations in many physiological
and biochemical functions. Over the last few decades, it has become clear that cancer cells …

Simple Summary Glioblastoma is a devastating malignancy that has continued to prove
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …

Background The overexpression of VEGFR-2 receptors in breast cancer provides a valuable
approach to anticancer strategies. Targeting VEGFR-2, a new semisynthetic compound (T-1 …

Since the discovery of phosphodiesterase-5 (PDE5) enzyme overexpression in the central
nervous system (CNS) malignancies, investigations have explored the potential capacity of …

Natural ingredients have been used in skincare products for thousands of years. The current
focus is on novel natural bioactivities that shield the skin from UV rays and free radicals …

The beneficial effects of coffee on human diseases are well documented, but the molecular
mechanisms of its bioactive compounds on cancer are not completely elucidated. This is …

Survival in glioblastoma remains poor despite advancements in standard-of-care treatment.
Some patients wish to take a more active role in their cancer treatment by adopting daily …

This chapter covers methylxanthines, with a focus on caffeine, theophylline, and
theobromine. The key topics of the chapter cover the chemical structure of methylxanthines …

The paucity of currently available therapies for glioblastoma multiforme requires novel
approaches to the treatment of this brain tumour. Disrupting cyclic nucleotide-signalling …

Despite the existing arsenal of anti‐cancer drugs, 10 million people die each year worldwide
due to cancers; this highlights the need to discover new therapies based on innovative …