The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …

As one of the most abundant and highly conserved molecular chaperones, the 70‐kDa heat
shock proteins (Hsp70s) play a key role in maintaining cellular protein homeostasis …

Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability
barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups) that regulate the …

Across the Tree of Life (ToL), the complexity of proteomes varies widely. Our systematic
analysis depicts that from the simplest archaea to mammals, the total number of proteins per …

The site of protein folding and maturation for the majority of proteins that are secreted,
localized to the plasma membrane or targeted to endomembrane compartments is the …

Hsp70s are among the most highly conserved proteins in all of biology. Through an iterative
binding and release of exposed hydrophobic residues on client proteins, Hsp70s can …

The Hsp70 family of chaperones works with its co-chaperones, the nucleotide exchange
factors and J-domain proteins, to facilitate a multitude of cellular functions. Central players in …

DNA methylation mediates silencing of transposable elements and genes in part via
recruitment of the Arabidopsis MBD5/6 complex, which contains the methyl-CpG binding …

Abstract Utilizing The Cancer Genome Atlas (TCGA) and KM plotter databases we identified
six heat shock proteins associated with survival of breast cancer patients. The survival …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …