The nuclear receptor superfamily: A structural perspective

ER Weikum, X Liu, EA Ortlund - Protein Science, 2018 - Wiley Online Library
Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Crystal structures of MBP fusion proteins

DS Waugh - Protein Science, 2016 - Wiley Online Library
Although chaperone‐assisted protein crystallization remains a comparatively rare
undertaking, the number of crystal structures of polypeptides fused to maltose‐binding …

Nuclear receptors as therapeutic targets in liver disease: are we there yet?

S Rudraiah, X Zhang, L Wang - Annual review of pharmacology …, 2016 - annualreviews.org
Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in
cell differentiation, development, proliferation, and metabolism and are associated with …

Advances in our structural understanding of orphan nuclear receptors

N Gallastegui, JAG Mackinnon, RJ Fletterick… - Trends in biochemical …, 2015 - cell.com
Nuclear receptors (NRs) are key players in the regulation of gene expression, coordinating
protein assemblies upon their surfaces. NRs are regulated by ligand binding, which …

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

C Benod, R Villagomez, CS Filgueira, PK Hwang… - PLoS …, 2014 - journals.plos.org
Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors.
Presently, no natural or synthetic ligand has been identified for a large group of orphan NRs …

[HTML][HTML] Structural overview and perspectives of the nuclear receptors, a major family as the direct targets forsmall-molecule drugs: Structural overview and …

F Li, C Song, Y Zhang, D Wu - Acta Biochimica et Biophysica Sinica, 2022 - ncbi.nlm.nih.gov
The nuclear receptors (NRs) are an evolutionarily related family of transcription factors,
which share certain common structural characteristics and regulate the expressions of …

Unexpected allosteric network contributes to LRH-1 co-regulator selectivity

PM Musille, BR Kossmann, JA Kohn, I Ivanov… - Journal of Biological …, 2016 - ASBMB
Phospholipids (PLs) are unusual signaling hormones sensed by the nuclear receptor liver
receptor homolog-1 (LRH-1), which has evolved a novel allosteric pathway to support …

[HTML][HTML] New insights into orphan nuclear receptor SHP in liver cancer

A Zou, S Lehn, N Magee, Y Zhang - Nuclear receptor research, 2015 - ncbi.nlm.nih.gov
Small heterodimer partner (SHP; NR0B2) is a unique orphan nuclear receptor (NR) that
contains a putative ligand-binding domain but lacks a DNA-binding domain. SHP is a …

TLX, an orphan nuclear receptor with emerging roles in physiology and disease

AT Nelson, Y Wang, ER Nelson - Endocrinology, 2021 - academic.oup.com
Abstract TLX (NR2E1), an orphan member of the nuclear receptor superfamily, is a
transcription factor that has been described to be generally repressive in nature. It has been …

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21

C Zhang, X Li, G Adelmant, J Dobbins… - Proceedings of the …, 2015 - National Acad Sciences
EP300-interacting inhibitor of differentiation 1 (EID1) belongs to a protein family implicated
in the control of transcription, differentiation, DNA repair, and chromosomal maintenance …