Sleep disorders and cancer: State of the art and future perspectives

MP Mogavero, LM DelRosso, F Fanfulla, O Bruni… - Sleep medicine …, 2021 - Elsevier
A bidirectional connection between sleep and cancer exists; however, the specific
associations between individual sleep disorders and particular tumors are not very clear. An …

Interconnection between circadian clocks and thyroid function

K Ikegami, S Refetoff, E Van Cauter… - Nature Reviews …, 2019 - nature.com
Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by
transcription–translation feedback loops of specific genes, which are referred to as 'circadian …

Metabolic rivalry: circadian homeostasis and tumorigenesis

K Kinouchi, P Sassone-Corsi - Nature Reviews Cancer, 2020 - nature.com
Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …

Circadian timing of metabolism in animal models and humans

C Dibner, U Schibler - Journal of internal medicine, 2015 - Wiley Online Library
Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …

Coupled network of the circadian clocks: a driving force of rhythmic physiology

AM Finger, C Dibner, A Kramer - FEBS letters, 2020 - Wiley Online Library
The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

Clocking cancer: the circadian clock as a target in cancer therapy

F Battaglin, P Chan, Y Pan, S Soni, M Qu, ER Spiller… - Oncogene, 2021 - nature.com
Disruption of the cellular pathway modulating endogenous 24-h rhythms, referred to as “the
circadian clock”, has been recently proven to be associated with cancer risk, development …

Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: mechanisms and interventions

R Fan, X Peng, L Xie, K Dong, D Ma, W Xu, X Shi… - Aging cell, 2022 - Wiley Online Library
With the aging world population, the prevalence of aging‐related disorders is on the rise.
Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's …

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

L Perrin, U Loizides-Mangold, S Chanon, C Gobet… - Elife, 2018 - elifesciences.org
Circadian regulation of transcriptional processes has a broad impact on cell metabolism.
Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial …

Associations between artificial light at night and risk for thyroid cancer: a large US cohort study

D Zhang, RR Jones, P James, CM Kitahara, Q Xiao - Cancer, 2021 - Wiley Online Library
Background Light at night (LAN) inhibits nighttime secretion of melatonin and may cause
circadian disruption, which may be a risk factor for cancer. Recent studies have linked high …

Circadian gene variants in cancer

NM Kettner, CA Katchy, L Fu - Annals of medicine, 2014 - Taylor & Francis
Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …