Since their discovery, heat shock proteins (HSPs) have been identified in all domains of life,
which demonstrates their importance and conserved functional role in maintaining protein …

Molecular chaperones are a family of proteins that maintain cellular protein homeostasis
through non-covalent peptide folding and quality control mechanisms. The chaperone …

Zinc is an essential element for human health. Among its many functions, zinc (II) modulates
the immune response to infections and, at high concentrations or in the presence of …

The human mitochondrial Hsp70, also called mortalin, is of considerable importance for
mitochondria biogenesis and the correct functioning of the cell machinery. In the …

Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial
targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery …

Abstract Mitochondrial Hsp70 (HSPA9, mtHsp70, mortalin) in conjunction with a complex set
of other proteins is involved in the transport of polypeptides across the mitochondrial matrix …

The role of mitochondria within a cell has grown beyond being the prime source of cellular
energy to one of the major signaling platforms. Recent evidence provides several insights …

Human 71 kDa heat shock cognate protein (HSPA8, also known as Hsc70, Hsp70-8, Hsc71,
Hsp71 or Hsp73) is a constitutively expressed chaperone that is critical for cell proteostasis …

Heat shock protein 90, an essential chaperone responsible for the correct maturation of key
proteins, has been confirmed to facilitate Bombyx mori nucleopolyhedrovirus (BmNPV) …

The Hsp70 family of heat shock proteins plays a critical function in maintaining cellular
homeostasis within various subcellular compartments. The human mitochondrial Hsp70 …