The pathology of malaria is caused by infection of red blood cells with unicellular
Plasmodium parasites. During blood-stage development, the parasite replicates within a …

Obligate intracellular malaria parasites reside within a vacuolar compartment generated
during invasion which is the principal interface between pathogen and host. To subvert their …

BioID is a well-established method for identifying protein–protein interactions and has been
utilized within live cells and several animal models. However, the conventional labeling …

Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a
nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary …

Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …

Plasmodium parasites contribute to one of the highest global infectious disease burdens. To
achieve this success, the parasite has evolved a range of specialized subcellular …

Membrane transport proteins, also known as transporters, control the movement of ions,
nutrients, metabolites, and waste products across the membranes of a cell and are central to …

Toxoplasma gondii is a ubiquitous, intracellular protozoan that extensively modifies infected
host cells through secreted effector proteins. Many such effectors must be translocated …

CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T
(Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through …

Intraerythrocytic malaria parasites reside within a parasitophorous vacuole membrane
(PVM) that closely overlays the parasite plasma membrane. Although the PVM is the site of …