Bone fractures and non-union defects often require surgical intervention where biomaterials
are used to correct the defect, and approximately 10% of these procedures are …

Infection of bone tissue, or osteomyelitis, has become a growing concern in modern
healthcare due in no small part to a rise in antibiotic resistance among bacteria, notably …

Infection is one of the pivotal causes of nonunion in large bone defect after trauma or tumor
resection. Three-dimensional (3D) composite scaffold with multifunctional-therapeutic …

Objectives Induced membrane technique is a relatively new technique in the reconstruction
of large bone defects. It involves the implantation of polymethylmethacrylate (PMMA) cement …

Repairing infected bone defects remains a challenge in clinical work. Intractable bacterial
infections and insufficient osseointegration are major concerns for infected bone defects. To …

Modern combat‐related injuries are often associated with acute polytrauma. As a
consequence of severe combat‐related injuries, a dysregulated immune response results in …

Objectives: To evaluate the effectiveness of locally applied vancomycin powder at different
times postinfection in a contaminated traumatic animal model. Methods: This study used an …

The local mechanical environment at a fracture is known to influence biological factors such
as callus formation, immune cell recruitment and susceptibility to infection. Infection models …

Systemic antibiotics reduce infection in open fractures. Local delivery of antibiotics can
provide higher doses to wounds without toxic systemic effects. This study investigated the …

Objective Osteosynthesis-associated infection is a challenging complication post fracture
fixation, burdening the patients and the orthopaedic surgeons alike. A clinically relevant …