Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …

Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

While diet-induced obesity has been exclusively attributed to increased caloric intake from
fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and …

Liver mitochondria undergo architectural remodeling that maintains energy homeostasis in
response to feeding and fasting. However, the specific components and molecular …

Lipid metabolism is fundamental to life. In insects, it is critical, during reproduction, flight,
starvation, and diapause. The coordination center for insect lipid metabolism is the fat body …

Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic
steatohepatitis (NASH)–induced liver fibrosis, but mechanisms underlying Notch reactivation …

Glucose homeostasis is regulated systemically by hormones such as insulin and glucagon,
and at the cellular level by energy status. Glucagon enhances glucose output from the liver …

The formation, maintenance and reorganization of synapses are critical for brain
development and the responses of neuronal circuits to environmental challenges. Here we …