Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Early brain injury after subarachnoid hemorrhage: incidence and mechanisms

DC Lauzier, K Jayaraman, JY Yuan, D Diwan… - Stroke, 2023 - Am Heart Assoc
Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant
morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in …

Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage

Y Cao, Y Li, C He, F Yan, JR Li, HZ Xu, JF Zhuang… - Neuroscience …, 2021 - Springer
Ferroptosis is a form of iron-dependent regulated cell death. Evidence of its existence and
the effects of its inhibitors on subarachnoid hemorrhage (SAH) is still lacking. In the present …

Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study

JP Dreier, MKL Winkler, S Major, V Horst, S Lublinsky… - Brain, 2022 - academic.oup.com
Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results
from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The …

INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats

X Hu, J Yan, L Huang, C Araujo, J Peng, L Gao… - Brain, behavior, and …, 2021 - Elsevier
Background Inflammasome-mediated neuroinflammation plays an important role in the
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …

Modifiable risk factors for intracranial aneurysm and aneurysmal subarachnoid hemorrhage: a mendelian randomization study

V Karhunen, MK Bakker, YM Ruigrok… - Journal of the …, 2021 - Am Heart Assoc
Background The aim of this study was to assess the associations of modifiable lifestyle
factors (smoking, coffee consumption, sleep, and physical activity) and cardiometabolic …

Perioperative management of aneurysmal subarachnoid hemorrhage: a narrative review

D Sharma - Anesthesiology, 2020 - pubs.asahq.org
Aneurysmal subarachnoid hemorrhage is an acute neurologic emergency. Prompt definitive
treatment of the aneurysm by craniotomy and clipping or endovascular intervention with …

Subarachnoid hemorrhage

S Muehlschlegel - Continuum: Lifelong Learning in Neurology, 2018 - journals.lww.com
PURPOSE OF REVIEW This article reviews the epidemiology, clinical presentation,
diagnosis, and management of patients with aneurysmal subarachnoid hemorrhage (SAH) …

The role of immune inflammation in aneurysmal subarachnoid hemorrhage

Z Zhang, Y Fang, C Lenahan, S Chen - Experimental Neurology, 2021 - Elsevier
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease, which mainly
caused by the rupture of an intracranial aneurysm. Clinical trials have demonstrated that …

Aneurysmal subarachnoid hemorrhage: current concepts and updates

C Rouanet, GS Silva - Arquivos de Neuro-Psiquiatria, 2019 - SciELO Brasil
Aneurysmal subarachnoid hemorrhage is a condition with a considerable incidence
variation worldwide. In Brazil, the exact epidemiology of aneurysmal SAH is unknown. The …