Small molecule tools for functional interrogation of protein tyrosine phosphatases
The importance of protein tyrosine phosphatases (PTPs) in the regulation of cellular
signalling is well established. Malfunction of PTP activity is also known to be associated with …
signalling is well established. Malfunction of PTP activity is also known to be associated with …
Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis
L Musumeci, MJ Kuijpers, K Gilio, A Hego, E Théâtre… - Circulation, 2015 - Am Heart Assoc
Background—A limitation of current antiplatelet therapies is their inability to separate
thrombotic events from bleeding occurrences. A better understanding of the molecular …
thrombotic events from bleeding occurrences. A better understanding of the molecular …
Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation
The hematopoietic protein tyrosine phosphatase (HePTP) is implicated in the development
of blood cancers through its ability to negatively regulate the mitogen-activated protein …
of blood cancers through its ability to negatively regulate the mitogen-activated protein …
[HTML][HTML] A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis
J Adams, BP Thornton, L Tabernero - International Journal of Molecular …, 2021 - mdpi.com
The kinase interaction motif protein tyrosine phosphatases (KIM-PTPs), HePTP, PTPSL and
STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) …
STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) …
High-throughput screening for protein tyrosine phosphatase activity modulators
L Tautz, EA Sergienko - Phosphatase Modulators, 2013 - Springer
Reversible phosphorylation of proteins, principally on serine, threonine, or tyrosine residues,
is central to the regulation of most aspects of eukaryotic cell function. Dysregulation of …
is central to the regulation of most aspects of eukaryotic cell function. Dysregulation of …
Synthesis and drug development of small molecule inhibitors of PTP1B
TL Wootton - 2023 - shura.shu.ac.uk
PTP1B (Protein tyrosine phosphatase 1B) is a member of the PTP (Protein tyrosine
phosphatase) family of proteins and has previously been identified as a potential therapeutic …
phosphatase) family of proteins and has previously been identified as a potential therapeutic …
FUNCTIONAL PROTEIN TYROSINE PHOSPHATASES IN PLATELETS
VV Inamdar - 2017 - scholarshare.temple.edu
Platelets are small anucleate cells in blood that are derived from megakaryocytes and their
primary function is to prevent bleeding. Upon vascular injury, the sub-endothelial collagen …
primary function is to prevent bleeding. Upon vascular injury, the sub-endothelial collagen …