[HTML][HTML] Stress-induced depression and Alzheimer's disease: focus on astrocytes

OV Dolotov, LS Inozemtseva, NF Myasoedov… - International journal of …, 2022 - mdpi.com
Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …

An astroglial basis of major depressive disorder? An overview

Q Wang, W Jie, JH Liu, JM Yang, TM Gao - Glia, 2017 - Wiley Online Library
Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Glial connexins and pannexins in the healthy and diseased brain

C Giaume, CC Naus, JC Sáez… - Physiological …, 2021 - journals.physiology.org
Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Therapeutic potential of astrocyte transplantation

N Hastings, WL Kuan, A Osborne… - Cell …, 2022 - journals.sagepub.com
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

J Lu, X Wang, A Wu, Y Cao, X Dai… - Phytotherapy …, 2022 - Wiley Online Library
The nervous system is one of the most complex physiological systems, and central nervous
system diseases (CNSDs) are serious diseases that affect human health. Ginseng (Panax …

Stress‐induced structural and functional modifications of astrocytes—Further implicating glia in the central response to stress

C Murphy‐Royal, GR Gordon, JS Bains - Glia, 2019 - Wiley Online Library
An organism's response to stress requires activation of multiple brain regions. This can have
long‐lasting effects on synaptic transmission and plasticity that likely provide adaptive …

[HTML][HTML] Pathological ATPergic signaling in major depression and bipolar disorder

P Illes, A Verkhratsky, Y Tang - Frontiers in molecular neuroscience, 2020 - frontiersin.org
The mood disorders, major depression (MD) and bipolar disorder (BD), have a high lifetime
prevalence in the human population and accordingly generate huge costs for health care …

[HTML][HTML] Connexin 43: an interface connecting neuroinflammation to depression

H Jiang, Y Zhang, ZZ Wang, NH Chen - Molecules, 2023 - mdpi.com
Major depressive disorder (MDD) is a leading chronic mental illness worldwide,
characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43) …

[HTML][HTML] The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication

A Fumagalli, J Heuninck, A Pizzoccaro… - Nature …, 2020 - nature.com
The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of
various cellular populations and its over-expression in tumors promotes cell proliferation …

Connexin 43: Insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy

N Zhang, Y Zhang, Z Wang, N Chen - Acta Pharmacologica Sinica, 2022 - nature.com
Major depressive disorder (MDD), a chronic and recurrent disease characterized by
anhedonia, pessimism or even suicidal thought, remains a major chronic mental concern …