Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Mass spectrometry imaging of biomolecular information

B Spengler - Analytical chemistry, 2015 - ACS Publications
Mass spectrometry imaging (MSI) has gone through a significant change over the last 3
years, the time span of this review. The predominant mass spectrometric method in …

Peak learning of mass spectrometry imaging data using artificial neural networks

WM Abdelmoula, BGC Lopez, EC Randall… - Nature …, 2021 - nature.com
Mass spectrometry imaging (MSI) is an emerging technology that holds potential for
improving, biomarker discovery, metabolomics research, pharmaceutical applications and …

Emerging computational methods in mass spectrometry imaging

H Hu, J Laskin - Advanced Science, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …

Ambient ionization mass spectrometry today and tomorrow: embracing challenges and opportunities

TH Kuo, EP Dutkiewicz, J Pei, CC Hsu - Analytical chemistry, 2019 - ACS Publications
Ambient ionization mass spectrometry (AIMS) has grown into a group of emerging analytical
techniques that allow rapid, real-time, high-throughput, in situ, and in vivo analysis in many …

A review of the medical hyperspectral imaging systems and unmixing algorithms' in biological tissues

A ul Rehman, SA Qureshi - Photodiagnosis and Photodynamic Therapy, 2021 - Elsevier
Hyperspectral fluorescence imaging (HFI) is a well-known technique in the medical research
field and is considered a non-invasive tool for tissue diagnosis. This review article gives a …

Mass spectrometry imaging to explore molecular heterogeneity in cell culture

T Bien, K Koerfer, J Schwenzfeier… - Proceedings of the …, 2022 - National Acad Sciences
Molecular analysis on the single-cell level represents a rapidly growing field in the life
sciences. While bulk analysis from a pool of cells provides a general molecular profile, it is …

Imaging mass spectrometry: instrumentation, applications, and combination with other visualization techniques

A Bodzon‐Kulakowska, P Suder - Mass spectrometry reviews, 2016 - Wiley Online Library
Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It
has unique ability to identify structures and to unravel molecular changes that occur in the …

A super-resolution strategy for mass spectrometry imaging via transfer learning

T Liao, Z Ren, Z Chai, M Yuan, C Miao, J Li… - Nature Machine …, 2023 - nature.com
High-spatial-resolution mass spectrometry imaging (HSR-MSI) provides precise spatial
information on thousands of biomolecules without labelling across a tissue section. Deep …

Mass spectrometry imaging in drug development

A Nilsson, RJA Goodwin, M Shariatgorji… - Analytical …, 2015 - ACS Publications
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …