Coordination, cooperation, competition, crowding and congestion of molecular motors: Theoretical models and computer simulations
Cytoskeletal motor proteins are biological nanomachines that convert chemical energy into
mechanical work to carry out various functions such as cell division, cell motility, cargo …
mechanical work to carry out various functions such as cell division, cell motility, cargo …
Self-organized optimal packing of kinesin-5-driven microtubule asters scales with cell size
N Khetan, G Pruliere, C Hebras… - Journal of cell …, 2021 - journals.biologists.com
Radial microtubule (MT) arrays or asters determine cell geometry in animal cells. Multiple
asters interacting with motors, such as those in syncytia, form intracellular patterns, but the …
asters interacting with motors, such as those in syncytia, form intracellular patterns, but the …
A typical workflow to simulate cytoskeletal systems with Cytosim
CA Lugo, E Saikia, F Nedelec - arXiv preprint arXiv:2205.13852, 2022 - arxiv.org
Many cytoskeletal systems are now sufficiently well known to permit their precise
quantitative modelling. Microtubule and actin filaments are well characterized, and the …
quantitative modelling. Microtubule and actin filaments are well characterized, and the …
Wave-like oscillations of clamped microtubules driven by collective dynein transport
Microtubules (MTs) are observed to move and buckle driven by ATP-dependent molecular
motors in both mitotic and interphasic eukaryotic cells as well as in specialized structures …
motors in both mitotic and interphasic eukaryotic cells as well as in specialized structures …
KnotResolver: tracking self-intersecting filaments in microscopy using directed graphs
Motivation Quantification of microscopy time series of in vitro reconstituted motor-driven
microtubule transport in “gliding assays” is typically performed using computational object …
microtubule transport in “gliding assays” is typically performed using computational object …
Quantification of cell shape, intracellular flows and transport based on DIC object detection and tracking
Computational image analysis combined with label‐free imaging has helped maintain its
relevance for cell biology, despite the rapid technical improvements in fluorescence …
relevance for cell biology, despite the rapid technical improvements in fluorescence …
Aster swarming by symmetry breaking of cortical dynein transport and coupling kinesins
Microtubule (MT) radial arrays or asters establish the internal topology of a cell by interacting
with organelles and molecular motors. We proceed to understand the general pattern …
with organelles and molecular motors. We proceed to understand the general pattern …
Number Dependence of Microtubule Collective Transport by Kinesin and Dynein
Translational motors that depend on cytoskeletal elements, either actin or tubulin, for their
activity are critical for cellular function in eukaryotes. Microtubule (MT)-dependent motors are …
activity are critical for cellular function in eukaryotes. Microtubule (MT)-dependent motors are …
Collective dynein transport of the nucleus by pulling on astral microtubules during Saccharomyces cerevisiae mitosis
Positioning the nucleus at the bud neck during Saccharomyces cerevisiae mitosis involves
pulling forces of cytoplasmic dynein localized in the daughter cell. Although genetic analysis …
pulling forces of cytoplasmic dynein localized in the daughter cell. Although genetic analysis …
Emergence of flagella-like oscillations in single microtubules driven by collective dynein transport
Flagellar and ciliary oscillations result from a combination of stereotypical axonemal
geometry, collective mechanics of motors, microtubules (MTs), elastic linkers and …
geometry, collective mechanics of motors, microtubules (MTs), elastic linkers and …