Coordination, cooperation, competition, crowding and congestion of molecular motors: Theoretical models and computer simulations

A Sen, D Chowdhury, A Kunwar - Advances in protein …, 2024 - pubmed.ncbi.nlm.nih.gov
Cytoskeletal motor proteins are biological nanomachines that convert chemical energy into
mechanical work to carry out various functions such as cell division, cell motility, cargo …

Self-organized optimal packing of kinesin-5-driven microtubule asters scales with cell size

N Khetan, G Pruliere, C Hebras… - Journal of cell …, 2021 - journals.biologists.com
Radial microtubule (MT) arrays or asters determine cell geometry in animal cells. Multiple
asters interacting with motors, such as those in syncytia, form intracellular patterns, but the …

A typical workflow to simulate cytoskeletal systems with Cytosim

CA Lugo, E Saikia, F Nedelec - arXiv preprint arXiv:2205.13852, 2022 - arxiv.org
Many cytoskeletal systems are now sufficiently well known to permit their precise
quantitative modelling. Microtubule and actin filaments are well characterized, and the …

Wave-like oscillations of clamped microtubules driven by collective dynein transport

SA Yadav, D Khatri, A Soni, N Khetan, CA Athale - Biophysical Journal, 2024 - cell.com
Microtubules (MTs) are observed to move and buckle driven by ATP-dependent molecular
motors in both mitotic and interphasic eukaryotic cells as well as in specialized structures …

KnotResolver: tracking self-intersecting filaments in microscopy using directed graphs

D Khatri, SA Yadav, CA Athale - Bioinformatics, 2024 - academic.oup.com
Motivation Quantification of microscopy time series of in vitro reconstituted motor-driven
microtubule transport in “gliding assays” is typically performed using computational object …

Quantification of cell shape, intracellular flows and transport based on DIC object detection and tracking

T Kale, D Khatri, J Basu, SA Yadav… - Journal of …, 2024 - Wiley Online Library
Computational image analysis combined with label‐free imaging has helped maintain its
relevance for cell biology, despite the rapid technical improvements in fluorescence …

Aster swarming by symmetry breaking of cortical dynein transport and coupling kinesins

N Khetan, CA Athale - Soft Matter, 2020 - pubs.rsc.org
Microtubule (MT) radial arrays or asters establish the internal topology of a cell by interacting
with organelles and molecular motors. We proceed to understand the general pattern …

Number Dependence of Microtubule Collective Transport by Kinesin and Dynein

K Jain, SA Yadav, CA Athale - Journal of the Indian Institute of Science, 2021 - Springer
Translational motors that depend on cytoskeletal elements, either actin or tubulin, for their
activity are critical for cellular function in eukaryotes. Microtubule (MT)-dependent motors are …

Collective dynein transport of the nucleus by pulling on astral microtubules during Saccharomyces cerevisiae mitosis

K Jain, N Khetan, SA Yadav, S Palani, CA Athale - Yeast, 2021 - Wiley Online Library
Positioning the nucleus at the bud neck during Saccharomyces cerevisiae mitosis involves
pulling forces of cytoplasmic dynein localized in the daughter cell. Although genetic analysis …

Emergence of flagella-like oscillations in single microtubules driven by collective dynein transport

SA Yadav, N Khetan, D Khatri, CA Athale - bioRxiv, 2022 - biorxiv.org
Flagellar and ciliary oscillations result from a combination of stereotypical axonemal
geometry, collective mechanics of motors, microtubules (MTs), elastic linkers and …