Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached
pandemic dimensions all over the world. The multifactorial nature of the pathology makes …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Diabetes mellitus is an important issue for public health, and it is growing in the world. In
recent years, there has been a growing research interest on efficacy evidence of the …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

The finding of studies on the effect of curcumin extract on metabolic factor in patients with
metabolic syndrome has had arguable results. This systematic review with meta‐analysis of …

Free fatty acids (FFAs) exert both positive and negative effects on beta cell survival and
insulin secretory function, depending on concentration, duration, and glucose abundance …

Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes
and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …