Adaptive laboratory evolution (ALE) is an evolutionary engineering approach in artificial
conditions that improves organisms through the imitation of natural evolution. Due to the …

Living organisms such as bacteria are often exposed to continuous changes in the nutrient
availability in nature. Therefore, bacteria must constantly monitor the environmental …

Hyaluronic acid (HA) is a member of the glycosaminoglycan family and has been widely
used in the clinical, medical, cosmetic and food industries. In this study, we constructed a …

L-valine is an essential amino acid and an important amino acid in the food and feed
industry. The relatively low titer and low fermentation yield currently limit the large-scale …

To date, most bio-based products of industrial biotechnology stem from sugar-based carbon
sources originating from food and feed competing resources. Exemplary for bioproducts …

L-valine is a valuable amino acid in mammals that is used as the main component of feed
additives. The low efficiency of the fermentation titer limits the industrial application of L …

Background Branched chain amino acids (BCAAs) are widely applied in the food,
pharmaceutical, and animal feed industries. Traditional chemical synthetic and enzymatic …

A unique feature of biotechnology is that we can harness the power of evolution to improve
process performance. Rational engineering of microbial strains has led to the establishment …

Abstract l-Valine is one of the three branched-chain amino acids (valine, leucine, and
isoleucine) essential for animal health and important in metabolism; therefore, it is widely …

L-valine is an essential amino acid that has wide and expanding applications with a
suspected growing market demand. Its applicability ranges from animal feed additive …