Highlights•Pili minor components play a key role in the regulation of pili mediated
activities.•Adhesion is a multifactorial effect; adhesins may function in an orchestrated …

Following the impact of the genomics revolution on vaccine research and the development
of reverse vaccinology, it was predicted that another new approach, structure-based antigen …

Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for
understanding the nature of immune responses and designing improved vaccines …

Introduction: The successful development of two broadly protective vaccines targeting
Neisseria meningitidis serogroup B (MenB); 4CMenB and rLP2086, is the most significant …

Recombinant protein-based vaccines are a valid and safer alternative to traditional vaccines
based on live-attenuated or killed pathogens. However, the immune response of subunit …

Bexsero® is a multicomponent vaccine composed of four major proteins of Neisseria
meningitidis: the fHbp, NHBA, NadA and PorA. This vaccine was licensed against invasive …

Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the
survival of the bacterium in human blood and a component of two recently licensed vaccines …

Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The first broad-
spectrum multicomponent vaccine against serogroup B meningococcus (MenB), 4CMenB …

Gram-negative pathogens are enveloped by an outer membrane that serves as a double-
edged sword: On the one hand, it provides a layer of protection for the bacterium from …

The use of protein X-ray crystallography for structure-based design of small-molecule drugs
is well-documented and includes several notable success stories. However, it is less well …