The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

The p K a values of 41 chiral phosphoric acid-family catalysts in DMSO were predicted using
the SMD/M06-2x/6-311++ G (2df, 2p)//B3LYP/6-31+ G (d) method for the first time. The study …

One of the leading goals in contemporary chemical catalysis is to render improved efficiency
to existing catalytic protocols. A few pertinent trends can readily be noticed from the current …

This Minireview summarizes strategies and developments regarding the use of hydrazones
as reagents in asymmetric organocatalysis, their distinct roles in nucleophile–electrophile …

Highly diastereo-and enantioselective Mukaiyama aldol reaction catalyzed by a new chiral
Brønsted acid, N-(perfluorooctanesulfonyl) thiophosphoramide, is described. The …

Over the last several years there has been a huge increase in the development and
applications of new efficient organocatalysts for enantioselective pericyclic reactions, which …

Catalytic asymmetric 1, 3-dipolar cycloadditions offer expeditious ways to afford synthetically
important chiral heterocycles. Although a variety of 1, 3-dipoles can be employed in this …

Hydrazones derived from cycloalkenones undergo an enantioselective transannular formal
(3+ 2) cycloaddition catalyzed by a chiral phosphoric acid. The reaction provides high yields …