[HTML][HTML] Structural characterization of SARS-CoV-2: where we are, and where we need to be
G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …
humans in almost every country, causing the disease COVID-19. Since the start of the …
[HTML][HTML] The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …
[HTML][HTML] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
[HTML][HTML] SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
Summary Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …
[HTML][HTML] Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …
The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …
[HTML][HTML] SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response
A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative
progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to …
progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to …
[HTML][HTML] Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
M Severa, RA Diotti, MP Etna, F Rizzo, S Fiore… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …
The role of type I interferon in the treatment of COVID‐19
F Sodeifian, M Nikfarjam, N Kian… - Journal of medical …, 2022 - Wiley Online Library
Although significant research has been done to find effective drugs against coronavirus
disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 …
disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 …
Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications
D Singh, H Wasan, KH Reeta - Free Radical Biology and Medicine, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) continues to infect hundred thousands of people …
syndrome coronavirus 2 (SARS-CoV-2) continues to infect hundred thousands of people …