Apelin is an endogenous peptide ligand for the G protein-coupled receptor
APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts …

Human pluripotent stem cells (hPSCs), including both embryonic stem cells and induced
pluripotent stem cells, are the ideal cell sources for disease modeling, drug discovery, and …

Apela (also known as Elabela, Ende, and Toddler) is a small signaling peptide that activates
the G-protein-coupled receptor Aplnr to stimulate cell migration during zebrafish …

The poles of the heart and branchiomeric muscles of the face and neck are formed from the
cardiopharyngeal mesoderm within the pharyngeal apparatus. They are disrupted in …

Increasing evidence indicates that metabolism is implicated in the control of stem cell
identity. Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a …

Outflow tract (OFT) develops from cardiac progenitor cells in the second heart field (SHF)
domain. APJ, a G-Protein Coupled Receptor, is expressed by cardiac progenitors in the …

Purpose The aim of this study was to investigate the function and mechanisms of ELABELA
(ELA) in the aerobic exercise-induced anti-apoptosis and angiogenesis of ischemic heart …

Aims The apelin receptor, a G protein-coupled receptor, has emerged as a key regulator of
cardiovascular development, physiology, and disease. However, there is a lack of suitable …

SWI/SNF chromatin-remodeling complexes are key regulators of the epigenetic
modifications that determine whether stem cells maintain pluripotency or commit toward …

The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration
of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGFβ …