This present review described the validation method of in-vitro bioassay for its application in
herbal drug research. Seven sequencing steps that can be taken for performing a valid …

Background: The thiazolide nitazoxanide (NTZ) is a broad-spectrum antiinfective drug that
adversely affects viability, growth, and proliferation of a range of extracellular and …

Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because
of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide …

Human le ishmaniasis is a vector-borne, neglected infectious disease that is widely
distributed in America, Africa, Europe, and Asia. Current therapy is based on old and toxic …

We have synthesized a new series of quinoline tripartite hybrids from chloroquine,
ethambutol, and isoxyl drugs, using a short synthetic route. Compounds 1–8 were tested in …

Current treatment for Chagas disease is based on only two drugs: benznidazole and
nifurtimox. Compounds containing sulfur (S) in their structure have shown promising results …

Combination of nitazoxanide (NTZ) with a total of 32 cocrystal formers gave cocrystals with
succinic acid (NTZ-SUC, 2: 1) and glutaric acid (NTZ-GLU, 1: 1). Additionally, 2, 5 …

Objectives In the prospection of possible agents against neglected diseases, thiazole
compounds are presented as promising candidates and are known to have activity against …

We report that the tuberculosis drug SQ109 [N-adamantan-2-yl-N′-((E)-3, 7-dimethyl-octa-
2, 6-dienyl)-ethane-1, 2-diamine] has potent activity against the intracellular amastigote form …

Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis
and African trypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence …