Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent
in most of anticancer drugs is their lack of tumor selectivity. Nanodrugs for cancer therapy …

Pericytes are specialized cells located in close proximity to endothelial cells within the
microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls …

Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …

Alzheimer's disease (AD) is an irrevocable neurodegenerative condition characterized by
the presence of senile plaques comprising amassed β-amyloid peptides (Aβ) and …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Background CSF-soluble platelet-derived growth factor receptor beta (sPDGFRβ) is closely
associated with pericyte damage. However, the changes in CSF sPDGFRβ levels and their …

Background Blood-brain barrier (BBB) disruption and gut microbiota dysbiosis play crucial
roles in Alzheimer's disease (AD). Lipopolysaccharide (LPS) stimulation triggered by gut …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that leads to
progressive cognitive decline and neuropathological changes. Pericytes, which are vessel …

Fracture healing is a complex process involving various cell types, cytokines, and mRNAs.
Here, we report the roles of the circRNA AFF4/miR-7223-5p/PIK3R1 axis during fracture …

Learning and memory formation rely on the precise spatiotemporal regulation of gene
expression, such as microRNA (miRNA)-associated silencing, to fine-tune gene expression …