Pathogenic mechanisms following ischemic stroke

SE Khoshnam, W Winlow, M Farzaneh, Y Farbood… - Neurological …, 2017 - Springer
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Understanding the connection between common stroke comorbidities, their associated inflammation, and the course of the cerebral ischemia/reperfusion cascade

Ł Przykaza - Frontiers in immunology, 2021 - frontiersin.org
Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

[HTML][HTML] Inflammation after ischemic stroke: the role of leukocytes and glial cells

JY Kim, J Park, JY Chang, SH Kim… - Experimental …, 2016 - ncbi.nlm.nih.gov
The immune response after stroke is known to play a major role in ischemic brain
pathobiology. The inflammatory signals released by immune mediators activated by brain …

Blood–brain barrier pathophysiology in traumatic brain injury

A Chodobski, BJ Zink… - Translational stroke …, 2011 - Springer
The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Ischemic cell death in brain neurons

P Lipton - Physiological reviews, 1999 - journals.physiology.org
This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Inflammatory responses in brain ischemia

M Kawabori, M A. Yenari - Current medicinal chemistry, 2015 - benthamdirect.com
Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets

JY Kim, M Kawabori, MA Yenari - Current medicinal chemistry, 2014 - ingentaconnect.com
Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

Post‐ischemic brain damage: pathophysiology and role of inflammatory mediators

D Amantea, G Nappi, G Bernardi, G Bagetta… - The FEBS …, 2009 - Wiley Online Library
Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia,
exerting either deleterious effects on the progression of tissue damage or beneficial roles …

Regulation of intercellular adhesion molecule‐1 (CD54) gene expression

KA Roebuck, A Finnegan - Journal of leukocyte biology, 1999 - Wiley Online Library
Abstract Intercellular adhesion molecule‐1 (ICAM‐1, CD54) is an inducible cell adhesion
glycoprotein of the immunoglobulin supergene family expressed on the surface of a wide …

Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes

P Kanikarla-Marie, SK Jain - Free Radical Biology and Medicine, 2016 - Elsevier
Diets that boost ketone production are increasingly used for treating several neurological
disorders. Elevation in ketones in most cases is considered favorable, as they provide …