The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Angiogenesis, a new vessel formation from the pre-existing ones, is essential for embryonic
development, wound repair and treatment of ischemic heart and limb diseases. However …

Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Retinal and choroidal neovascularization are a major cause of significant visual impairment,
worldwide. Understanding the various factors involved in the accompanying …

Disturbed cell autophagy is found in various cardiovascular disease conditions.
Biomechanical stimuli induced by laminar blood flow have important protective actions …

Our understanding of the role of oxygen in cell physiology has evolved from its long-
recognized importance as an essential factor in oxidative metabolism to its recognition as an …

There exist two opposing perspectives regarding reactive oxygen species (ROS) and their
roles in angiogenesis and cardiovascular system, one that favors harmful and causal effects …

We recently reported that increased NADPH oxidase 4 (NOX4) expression and activity
during aging results in enhanced cellular and mitochondrial oxidative stress, vascular …

Marfan syndrome (MFS) is characterized by the formation of ascending aortic aneurysms
resulting from altered assembly of extracellular matrix fibrillin-containing microfibrils and …

Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the
triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic …