Background: Hypericin is a prominent secondary metabolite mainly existing in genus
Hypericum. It has become a research focus for a quiet long time owing to its extensively …

Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …

For almost two years, the COVID-19 pandemic has constituted a major challenge to human
health, particularly due to the lack of efficient antivirals to be used against the virus during …

Antioxidant defense mechanisms are important for a parasite to overcome oxidative stress
and survive within host macrophage cells. Mitochondrial iron superoxide dismutase A …

Since Leishmania parasites exhibit resistance outbreaks to drugs conventionally used in
medical treatments, research of new antileishmanial compounds or alternative treatment …

In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole
unique metabolism, where most enzymes are essential for parasitic survival and infectivity …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Leishmania donovani, an obligatory intracellular flagellate pathogen, is the underlying
cause of visceral leishmaniasis (VL), a fatal disease that poses a significant challenge to …

An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-
spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was …

Abstract Ethnopharmacological relevance Species of Vismia (Hypericaceae), known in
Brazil as “lacre”, are commonly used in traditional Amazonian medicine for the treatment of …