A central goal of neuroscience is to understand how the brain transforms external stimuli
and internal bodily signals into patterns of activity that underlie cognition, emotional states …

Social competition determines hierarchical social status, which profoundly influences
animals' behavior and health. The dorsomedial prefrontal cortex (dmPFC) plays a …

It is well established that the basolateral amygdala (BLA) is an emotional processing hub
that governs a diverse repertoire of behaviors. Selective engagement of a heterogeneous …

The basolateral amygdala (BLA) is reliably activated by psychological stress and
hyperactive in conditions of pathological stress or trauma; however, subsets of BLA neurons …

Processing emotionally meaningful stimuli and eliciting appropriate valence-specific
behavior in response is a critical brain function for survival. Thus, how positive and negative …

Negative bias is an essential characteristic of depressive episodes leading patients to
attribute more negative valence to environmental cues. This negative bias affects all levels …

Accumulating evidence supports a role for altered circuit function in impaired valence
processing and altered affective states as a core feature of psychiatric illnesses. We review …

The presence of valence coding neurons in the basolateral amygdala (BLA) that form
distinct projections to other brain regions implies functional opposition between aversion …

Significance Microprism-mediated calcium imaging of deep brain structures allows for
reliable tracking of thousands of cells across days, a marked improvement compared with …

Sensory stimuli associated with aversive outcomes cause multiple behavioral responses
related to an animal's evolving emotional state, but neural mechanisms underlying these …