Excitotoxicity: still hammering the ischemic brain in 2020
DW Choi - Frontiers in neuroscience, 2020 - frontiersin.org
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury
P Zong, J Feng, Z Yue, Y Li, G Wu, B Sun, Y He… - Neuron, 2022 - cell.com
Excitotoxicity induced by NMDA receptor (NMDAR) activation is a major cause of neuronal
death in ischemic stroke. However, past efforts of directly targeting NMDARs have …
death in ischemic stroke. However, past efforts of directly targeting NMDARs have …
[HTML][HTML] TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions
P Malko, LH Jiang - Redox biology, 2020 - Elsevier
Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …
Mouse models of Down syndrome: gene content and consequences
M Gupta, AR Dhanasekaran, KJ Gardiner - Mammalian Genome, 2016 - Springer
Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is challenging to model in
mice. Not only is it a contiguous gene syndrome spanning 35 Mb of the long arm of Hsa21 …
mice. Not only is it a contiguous gene syndrome spanning 35 Mb of the long arm of Hsa21 …
Sex differences in mitochondrial (dys) function: Implications for neuroprotection
TG Demarest, MM McCarthy - Journal of bioenergetics and biomembranes, 2015 - Springer
Decades of research have revealed numerous differences in brain structure size,
connectivity and metabolism between males and females. Sex differences in …
connectivity and metabolism between males and females. Sex differences in …
TRPM2: a candidate therapeutic target for treating neurological diseases
JC Belrose, MF Jackson - Acta Pharmacologica Sinica, 2018 - nature.com
Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …
Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice
Q Zhou, X Fu, J Xu, S Dong, C Liu, D Cheng, C Gao… - Neuron, 2023 - cell.com
Precise monitoring of internal temperature is vital for thermal homeostasis in mammals. For
decades, warm-sensitive neurons (WSNs) within the preoptic area (POA) were thought to …
decades, warm-sensitive neurons (WSNs) within the preoptic area (POA) were thought to …
The transient receptor potential melastatin 2 (TRPM2) channel contributes to β-amyloid oligomer-related neurotoxicity and memory impairment
VG Ostapchenko, M Chen, MS Guzman… - Journal of …, 2015 - Soc Neuroscience
In Alzheimer's disease, accumulation of soluble oligomers of β-amyloid peptide is known to
be highly toxic, causing disturbances in synaptic activity and neuronal death. Multiple …
be highly toxic, causing disturbances in synaptic activity and neuronal death. Multiple …
Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?
MV Caldeira, IL Salazar, M Curcio… - Progress in …, 2014 - Elsevier
The ubiquitin–proteasome system (UPS) is a catalytic machinery that targets numerous
cellular proteins for degradation, thus being essential to control a wide range of basic …
cellular proteins for degradation, thus being essential to control a wide range of basic …