The role of histamine in neurogenic inflammation
AC Rosa, R Fantozzi - British journal of pharmacology, 2013 - Wiley Online Library
The term 'neurogenic inflammation'has been adopted to describe the local release of
inflammatory mediators, such as substance P and calcitonin gene‐related peptide, from …
inflammatory mediators, such as substance P and calcitonin gene‐related peptide, from …
Mast cells on the mind: new insights and opportunities
Mast cells (MCs) are both sensors and effectors in communication among nervous, vascular,
and immune systems. In the brain, they reside on the brain side of the blood–brain barrier …
and immune systems. In the brain, they reside on the brain side of the blood–brain barrier …
[PDF][PDF] A mast-cell-specific receptor mediates neurogenic inflammation and pain
Mast cells can be found in close proximity to peripheral nerve endings where, upon
activation, they release a broad range of pro-inflammatory cytokines and chemokines …
activation, they release a broad range of pro-inflammatory cytokines and chemokines …
Immune actions on the peripheral nervous system in pain
JA Liu, J Yu, CW Cheung - International journal of molecular sciences, 2021 - mdpi.com
Pain can be induced by tissue injuries, diseases and infections. The interactions between
the peripheral nervous system (PNS) and immune system are primary actions in pain …
the peripheral nervous system (PNS) and immune system are primary actions in pain …
Divergent roles of immune cells and their mediators in pain
R Raoof, HLDM Willemen, N Eijkelkamp - Rheumatology, 2018 - academic.oup.com
Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …
Mast cells in the developing brain determine adult sexual behavior
KM Lenz, LA Pickett, CL Wright, KT Davis… - Journal of …, 2018 - Soc Neuroscience
Many sex differences in brain and behavior are programmed during development by
gonadal hormones, but the cellular mechanisms are incompletely understood. We found that …
gonadal hormones, but the cellular mechanisms are incompletely understood. We found that …
Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1
W Gao, Y Zan, ZJ Wang, X Hu, F Huang - Acta Pharmacologica Sinica, 2016 - nature.com
Aim: Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since
paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid …
paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid …
Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes
Background Mast cell (MC) progenitors leave the bone marrow, enter the circulation, and
settle in the skin and other tissues. Their maturation in tissues is influenced by the …
settle in the skin and other tissues. Their maturation in tissues is influenced by the …
[HTML][HTML] Serpins in tick physiology and tick-host interaction
MN Abbas, A Chlastáková, MA Jmel… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick saliva has been extensively studied in the context of tick-host interactions because it is
involved in host homeostasis modulation and microbial pathogen transmission to the host …
involved in host homeostasis modulation and microbial pathogen transmission to the host …
Molecular and cellular mechanisms that initiate pain and itch
Somatosensory neurons mediate our sense of touch. They are critically involved in
transducing pain and itch sensations under physiological and pathological conditions, along …
transducing pain and itch sensations under physiological and pathological conditions, along …