Proteins that bind both DNA and RNA typify the ability of a single gene product to perform
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …

Highlights•Traditional aptamers fold into structures with established nucleic acid
motifs.•Modified nucleotides expand the repertoire of known nucleic acid structural …

Aptamers represent a potentially important class of ligands for the development of
diagnostics and therapeutics. However, it is often difficult to compare the function and …

Aptamers are promising therapeutic and diagnostic agents for various diseases due to their
high affinity and specificity against target proteins. Structural determination in combination …

Aptamers are single-stranded oligonucleotides (RNA or DNA) with a typical length between
25 and 100 nucleotides which fold into three-dimensional structures capable of binding to …

Cancer is one of the leading causes of death around the world. Tumor-targeted drug
delivery is one of the major areas in cancer research. Aptamers exhibit many desirable …

The past decade has seen an explosion in discovery of small, non‐coding RNAs in all
organisms. As functions for many of the small RNAs have been identified, it has become …

Aptamers are nucleic acids that bind to a target molecule with high affinity and specificity,
which are selected from systematic evolution of ligands by exponential enrichment (SELEX) …

Summary In Saccharomyces cerevisiae, the Ku heterodimer contributes to telomere
maintenance as a component of telomeric chromatin and as an accessory subunit of …

Aptamers are synthetic nucleic acids that are developed to target with high affinity and
specificity chemical entities ranging from single ions to macromolecules and present a wide …