The structure, function and evolution of proteins that bind DNA and RNA
WH Hudson, EA Ortlund - Nature reviews Molecular cell biology, 2014 - nature.com
Proteins that bind both DNA and RNA typify the ability of a single gene product to perform
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …
[HTML][HTML] Embracing proteins: structural themes in aptamer–protein complexes
AD Gelinas, DR Davies, N Janjic - Current opinion in structural biology, 2016 - Elsevier
Highlights•Traditional aptamers fold into structures with established nucleic acid
motifs.•Modified nucleotides expand the repertoire of known nucleic acid structural …
motifs.•Modified nucleotides expand the repertoire of known nucleic acid structural …
A comparative analysis of cell surface targeting aptamers
L Kelly, KE Maier, A Yan, M Levy - Nature Communications, 2021 - nature.com
Aptamers represent a potentially important class of ligands for the development of
diagnostics and therapeutics. However, it is often difficult to compare the function and …
diagnostics and therapeutics. However, it is often difficult to compare the function and …
Structural biology for the molecular insight between aptamers and target proteins
N Zhang, Z Chen, D Liu, H Jiang, ZK Zhang… - International Journal of …, 2021 - mdpi.com
Aptamers are promising therapeutic and diagnostic agents for various diseases due to their
high affinity and specificity against target proteins. Structural determination in combination …
high affinity and specificity against target proteins. Structural determination in combination …
Therapeutic Potential of Aptamer–Protein Interactions
AS Shraim, BA Abdel Majeed… - ACS Pharmacology & …, 2022 - ACS Publications
Aptamers are single-stranded oligonucleotides (RNA or DNA) with a typical length between
25 and 100 nucleotides which fold into three-dimensional structures capable of binding to …
25 and 100 nucleotides which fold into three-dimensional structures capable of binding to …
Tumor-targeted drug delivery with aptamers
Cancer is one of the leading causes of death around the world. Tumor-targeted drug
delivery is one of the major areas in cancer research. Aptamers exhibit many desirable …
delivery is one of the major areas in cancer research. Aptamers exhibit many desirable …
6S RNA: a regulator of transcription
KM Wassarman - Molecular microbiology, 2007 - Wiley Online Library
The past decade has seen an explosion in discovery of small, non‐coding RNAs in all
organisms. As functions for many of the small RNAs have been identified, it has become …
organisms. As functions for many of the small RNAs have been identified, it has become …
Thermodynamic study of aptamers binding to their target proteins
T Sakamoto, E Ennifar, Y Nakamura - Biochimie, 2018 - Elsevier
Aptamers are nucleic acids that bind to a target molecule with high affinity and specificity,
which are selected from systematic evolution of ligands by exponential enrichment (SELEX) …
which are selected from systematic evolution of ligands by exponential enrichment (SELEX) …
[HTML][HTML] Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model
JS Pfingsten, KJ Goodrich, C Taabazuing, F Ouenzar… - Cell, 2012 - cell.com
Summary In Saccharomyces cerevisiae, the Ku heterodimer contributes to telomere
maintenance as a component of telomeric chromatin and as an accessory subunit of …
maintenance as a component of telomeric chromatin and as an accessory subunit of …
[HTML][HTML] Structural Insights into Protein–Aptamer Recognitions Emerged from Experimental and Computational Studies
Aptamers are synthetic nucleic acids that are developed to target with high affinity and
specificity chemical entities ranging from single ions to macromolecules and present a wide …
specificity chemical entities ranging from single ions to macromolecules and present a wide …