The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

The past decade has seen a remarkable explosion in our knowledge of the size and
diversity of the myosin superfamily. Since these actin-based motors are candidates to …

Blebbistatin is a recently discovered small molecule inhibitor showing high affinity and
selectivity toward myosin II. Here we report a detailed investigation of its mechanism of …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Myosins and kinesins are molecular motors that hydrolyse ATP to track along actin filaments
and microtubules, respectively. Although the kinesin family includes motors that move …

Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …

I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Molecular motors are protein machines whose directed movement along cytoskeletal
filaments is driven by ATP hydrolysis. Eukaryotic cells contain motors that help to transport …

Blebbistatin is a small molecule inhibitor discovered in a screen for inhibitors of nonmuscle
myosin IIA. We have examined the specificity and potency of the drug by assaying its effects …

In the past few years genetic, biochemical, and cytolocalization data have implicated
members of the myosin superfamily of actin-based molecular motors in a variety of cellular …