[HTML][HTML] The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
J Feng, K Chen, S Shen, Y Luo, X Liu, X Chen… - Biomedicine & …, 2023 - Elsevier
Corydalis yanhusuo WT Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one
of the herb components of many Chinese Traditional Medicine prescriptions such as Jin …
of the herb components of many Chinese Traditional Medicine prescriptions such as Jin …
Anti-acetylcholinesterase mechanism of kaempferol and its synergistic effect with galanthamine hydrobromide
W Shi, G Zhang, Y Liao, X Fei, D Gong, X Hu - Food Bioscience, 2023 - Elsevier
Kaempferol, a natural flavonoid compound, was found to suppress the activity of AChE in a
reversible mixed-inhibition with an IC 50 value of 12.43±0.19 μM. Fluorescence spectra …
reversible mixed-inhibition with an IC 50 value of 12.43±0.19 μM. Fluorescence spectra …
Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses
YJ Li, CC Liang, L Jin, J Chen - Spectrochimica Acta Part A: Molecular and …, 2023 - Elsevier
Acetylcholinesterase (AChE) is an important therapeutic target for the treatment of
Alzheimer's disease (AD), and the development of natural AChE inhibitors as candidates …
Alzheimer's disease (AD), and the development of natural AChE inhibitors as candidates …
Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine
W Shi, W Han, Y Liao, J Wen, G Zhang - Spectrochimica Acta Part A …, 2024 - Elsevier
The search for acetylcholinesterase (AChE) inhibitors produced by natural sources is of
great significance for the prevention and therapy of Alzheimer's disease and has been …
great significance for the prevention and therapy of Alzheimer's disease and has been …
Palmatine attenuates LPS‐induced neuroinflammation through the PI3K/Akt/NF‐κB pathway
J Zeng, H Pei, H Wu, W Chen, R Du… - Journal of Biochemical …, 2024 - Wiley Online Library
To investigate the key molecular mechanisms of palmatine for the treatment of
neuroinflammation through modulation of a pathway using molecular docking, molecular …
neuroinflammation through modulation of a pathway using molecular docking, molecular …
Roles of hybrid donepezil scaffolds as potent human acetylcholinesterase inhibitors using in silico interaction analysis, drug-likeness, and pharmacokinetics prediction
P Honorio, S Hannongbua, P Saparpakorn - Chemico-Biological …, 2022 - Elsevier
Acetylcholinesterase (AChE) is currently one of the potent targets for the treatment of
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …
Molecular engineering and activity improvement of acetylcholinesterase inhibitors: Insights from 3D-QSAR, docking, and molecular dynamics simulation studies
W Gao, X Ma, H Yang, Y Luan, H Ai - Journal of Molecular Graphics and …, 2022 - Elsevier
The carbamate molecule rivastigmine was found to possess promising anti-
acetylcholinesterase activity, enabling to target and occupy choline binding sites, and as a …
acetylcholinesterase activity, enabling to target and occupy choline binding sites, and as a …
Binding interactions and in silico ADME prediction of isoconessimine derivatives as potent acetylcholinesterase inhibitors
P Tue-Ngeun, W Rakitikul, N Thinkumrob… - Journal of Molecular …, 2024 - Elsevier
In pursuit of new acetylcholinesterase (AChE) inhibitors for treating Alzheimer's disease
(AD), a series of ten previously synthesized isoconessimine compounds (7a-7j) was in silico …
(AD), a series of ten previously synthesized isoconessimine compounds (7a-7j) was in silico …
Elucidation of benzene sulfonamide derivative binding at a novel interprotomer pocket of wild type and mutants of coxsackievirus B3 viral capsid using molecular …
P Prapassornwattana, S Hannongbua… - Biophysical …, 2023 - Elsevier
Abstract Coxsackievirus B3 (CVB3), a serotype of enterovirus B, causes hand, foot, and
mouth disease; pericarditis; and myocarditis. A benzene sulfonamide derivative is reported …
mouth disease; pericarditis; and myocarditis. A benzene sulfonamide derivative is reported …
Insight investigation of rilpivirine and compounds from mushrooms as feline immunodeficiency virus reverse transcriptase inhibitors using molecular dynamics …
P Saparpakorn, A Chimprasit, T Jantarat… - Molecular …, 2022 - Taylor & Francis
Because the pathogenesis of feline immunodeficiency virus (FIV) is similar to the human
immunodeficiency virus (HIV) infection, FIV is also used as a model for the drug discovery of …
immunodeficiency virus (HIV) infection, FIV is also used as a model for the drug discovery of …