In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

For more than a century, physicians have searched for ways to pharmacologically reduce
excess body fat. The tide has finally turned with recent advances in biochemically …

Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1),
glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have …

With their ever-growing prevalence, obesity and diabetes represent major health threats of
our society. Based on estimations by the World Health Organization, approximately 300 …

G-protein-coupled receptors (GPCRs) are activated by a diverse range of ligands, from large
proteins and proteases to small peptides, metabolites, neurotransmitters and ions. They are …

Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …

Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative
regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in …

Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by
promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic …

To better understand human health and disease, researchers create a wide variety of mouse
models that carry human DNA. With recent advances in genome engineering, the targeted …

Background Women with a history of gestational diabetes mellitus (GDM) have a 7-fold
higher risk of developing type 2 diabetes (T2D) during midlife and an elevated risk of …