Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …

IgH class switching occurs rapidly after activation of mature naive B cells, resulting in a
switch from expression of IgM and IgD to expression of IgG, IgE, or IgA; this switch improves …

Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin
heavy chain locus (Igh) Cμ constant region exons (CHs) with one of six CHs lying 100–200 …

Faithful transmission of genetic material is crucial for all organisms since changes in genetic
information may result in genomic instability that causes developmental disorders and …

Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics
plays a pivotal role in regulating the malignant phenotype, and has the potential in …

The end joining of distant DNA double-strand ends (DSEs) can produce potentially
deleterious rearrangements. We show that depletion of cohesion complex proteins …

The NIPBL/MAU2 heterodimer loads cohesin onto chromatin. Mutations in NIPBL account
for most cases of the rare developmental disorder Cornelia de Lange syndrome (CdLS) …

To the Editor: Around the Mediterranean basin, Cupressaceae pollen is considered as the
primary cause of respiratory allergies with symptoms of rhinoconjunctivitis, chronic cough …

The autosomal recessive immunodeficiency, centromeric instability, and facial anomalies
(ICF) syndrome is a genetically heterogeneous disorder. Despite the identification of the …

During B cell development, long-distance DNA interactions are needed for V (D) J somatic
rearrangement of the immunoglobulin (Ig) loci to produce functional Ig genes, and for class …