The systematic sequencing of glioblastoma multiforme (GBM) genomes has identified the
recurrent mutation of IDH1, a gene encoding NADP+-dependent isocitrate dehydrogenase 1 …

Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …

Cell-based assays represent approximately half of all high-throughput screens currently
performed. Here, we review in brief the history and status of high-throughput screening …

Target Identification in Chemical Genetics: Chemistry & Biology Skip to Main Content
Advertisement Cell Chemical Biology This journal offers authors two options (open access or …

Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate, utilizing
NADH as a cofactor. It has been identified as a potential therapeutic target in the area of …

Fragment-based lead discovery constructs drug leads from small molecular fragments. In
theory, this is a highly efficient method for drug discovery, and the technique has become …

The latest findings on the role played by human LDH5 (h LDH5) in the promotion of
glycolysis in invasive tumor cells indicates that this enzyme subtype is a promising …

Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in
the glycolysis pathway. Cancer cells rely heavily on glycolysis instead of oxidative …

Many of today's drug discovery programs use high-throughput screening methods that rely
on quick evaluations of protein activity to rank potential chemical leads. By monitoring …

Bacterial resistance continues to develop and pose a significant threat, both in hospitals
and, more recently, in the community. A focus on other therapeutic areas by the larger …