Diaryl ether (DE) is a functional scaffold existing widely both in natural products (NPs) and
synthetic organic compounds. Statistically, DE is the second most popular and enduring …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

In our endeavour towards the development of potent cytotoxic agents, a series of some new
curcumin inspired indole analogues, in which indole and phenyl moieties are linked on …

Synthetically established methods for methylation of phenols and demethylation of methyl
phenyl ethers rely in general on hazardous reagents or/and harsh reaction conditions and …

This chapter will discuss the recent literature of macrocycles and drug-like property space
moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this …

Abstract Based on perlolyrine (1), a natural alkaloid with weak PDE5 potency from the
traditional Chinese aphrodisiac plant Tribulus terrestris L., a series α-substituted tetrahydro …

Iodine is one of the most effective sources for iodination of aromatic compounds; however,
its electrophilicity is insufficient for direct iodination. The selection of appropriate …

A series of novel nitrogen-containing macrocyclic bisbibenzyl derivatives was designed,
synthesized, and evaluated for antiproliferative activity against three anthropic cancer cell …

Based on our previous studies and predictive docking results, furans and thiophenes were
introduced to the privileged tetrahydro-β-carboline scaffold to generate more potent and …

Abstract A series of 3, 6-diaryl-1H-pyrazolo [5, 1-c][1, 2, 4] triazoles (I) and 3, 6-diaryl-[1, 2, 4]
triazolo [3, 4-b][1, 3, 4] thiadiazoles (II) as antitubulin agents were designed, synthesized and …