Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Abstract α-Synuclein (α-syn) amyloid fibrils are the major component of Lewy bodies, which
are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. High …

Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …

Lipids play a more significant role in Parkinson's disease and its related brain disorders than
is currently recognized, supporting a “lipid cascade”. The 14 kDa protein α-synuclein (αS) is …

Paraformaldehyde (PFA) is the most commonly used fixative for immunostaining of cells, but
has been associated with various problems, ranging from loss of antigenicity to changes in …

Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons, a
process that current therapeutic approaches cannot prevent. In PD, the typical pathological …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

Key points Parkinson's disease (PD) is a frequent neurodegenerative disease with a
premotor phase that lasts several years. Risk factors that have been linked to PD are …