Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Hyperforin is a prenylated phloroglucinol present in the medicinal plant St John's wort
(Hypericum perforatum). The compound has many biological properties, including …

Chronic unpredictable mild stress (CUMS)-a rodent model of depression mimics a variety of
neurochemical and behavioral alterations similar to those seen in human depression. This …

Hyperforin is one of the main bioactive compounds that underlie the antidepressant actions
of the medicinal plant Hypericum perforatum (St. John's wort). However, the effects of a …

Hyperforin (HPF), the main component responsible for the antidepressant action of
Hypericum perforatum, displays additional beneficial properties including anti-inflammatory …

Hyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum
perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro …

Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative
of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts …

Clinical and preclinical studies show evidence that chronic stress or nutritional deficits in
dietary zinc (Zn) intake may be risk factors for developing major depressive disorder (MDD) …

St. John's wort has been the subject of studies focused on its therapeutic properties against
several diseases, including Alzheimer's disease (AD). Amyloid β-peptide (Aβ), a critical …

Many physiological processes like muscle contraction, hormone secretion and intracellular
signalling processes are triggered by calcium as intracellular signalling molecule. The …