X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

In biology as in real estate, location is a cardinal organizational principle that dictates the
accessibility and flow of informational traffic. An essential question in nuclear organization is …

Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

A large number of cis-regulatory sequences have been annotated in the human genome,,
but defining their target genes remains a challenge. One strategy is to identify the long …

X-chromosome inactivation (XCI) involves major reorganization of the X chromosome as it
becomes silent and heterochromatic. During female mammalian development, XCI is …

In eukaryotes transcriptional regulation often involves multiple long-range elements and is
influenced by the genomic environment. A prime example of this concerns the mouse X …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …