Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Protein-restricted diets promote health and longevity in many species. While the precise
components of a protein-restricted diet that mediate the beneficial effects to longevity have …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Frailty can be viewed as a state of physiological decline that increases susceptibility to
adverse health outcomes. This loss of physiological reserve means that even small stressors …

Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Age‐related diseases represent some of the largest unmet clinical needs of our time. While
treatment of specific disease‐related signs has had some success (for example, the effect of …