[HTML][HTML] A review on synthetic account of 1, 2, 4-oxadiazoles as anti-infective agents

TM Dhameliya, SJ Chudasma, TM Patel, BP Dave - Molecular Diversity, 2022 - Springer
Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen
and or oxygen as heteroatoms in their structures. Several research groups have synthesized …

A comprehensive review of recent advances in the biological activities of 1, 2, 4‐oxadiazoles

OM Hendawy - Archiv der Pharmazie, 2022 - Wiley Online Library
Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …

Electrochemical synthesis of polysubstituted oxazoles from ketones and acetonitrile

L Bao, C Liu, W Li, J Yu, M Wang, Y Zhang - Organic Letters, 2022 - ACS Publications
Herein we report an electrochemical strategy for the construction of polysubstituted oxazoles
from easily available ketones and acetonitrile under room temperature. The method shows …

Electrochemical oxidation-induced benzylic C (sp 3)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

N Yang, A Li, H Gao, LM Liao, YP Yang, PL Wang… - Green …, 2023 - pubs.rsc.org
A unique electrochemical four-component reaction of terminal alkynes,(thio) xanthenes,
nitriles, and water has been established in the absence of any catalyst or external oxidant …

Organic acid to nitrile: a chemoenzymatic three‐step route

M Winkler, M Horvat, A Schiefer… - Advanced Synthesis …, 2023 - Wiley Online Library
Various widely applied compounds contain cyano‐groups, and this functional group serves
as a chemical handle for a whole range of different reactions. We report a cyanide free …

Advances in the Application of Acetonitrile in Organic Synthesis since 2018

P Zhong, L Zhang, N Luo, J Liu - Catalysts, 2023 - mdpi.com
Acetonitrile is commonly used as an organic solvent and can also be used as an important
intermediate in organic synthesis. Its widespread use has led to the development of new …

Photocatalytic Benzylic C–H Oxidation/Cyclization of Enaminones to the Synthesis of Polysubstituted Oxazoles

M Li, Z He, W Zhao, Y Yu, F Huang… - The Journal of Organic …, 2023 - ACS Publications
Photocatalytic benzylic C–H oxidation/cyclization of enaminones was efficiently achieved to
afford oxazole derivatives under mild conditions. The oxygen in the oxazole ring originated …

Sustainability in a can: upcycling aluminium scrap in the waste-minimized electrochemical synthesis of 2-oxazoline

ST Colangeli, F Ferlin, L Vaccaro - Green Chemistry, 2024 - pubs.rsc.org
The use and consumption of electrodes is a crucial aspect regarding the overall efficiency
and sustainability of electrochemical reactions. When metal electrodes are used, the cost of …

Synthesis and Antioxidant Properties of Novel Galloyloxadiazole Hybrids

NA Al Zahrani, RM El‐Shishtawy - Egyptian Journal of Chemistry, 2024 - journals.ekb.eg
Herein, the design, synthesis, and characterization of four novel galloyloxadiazole hybrids
are described. Compounds were evaluated in vitro as antioxidant agents by DPPH assay in …

Copper Loading-Controlled Selective Synthesis of 2, 5-Bis (trifluoromethyl) and Monotrifluoromethyl-Substituted Oxazoles

W Wu, Z Zhang, J Li, J Xia, X Han… - The Journal of Organic …, 2023 - ACS Publications
A general domino annulation reaction of sulfonylmethyl isocyanide with trifluoroacetic
anhydride in the presence of copper chloride as an additive is developed. The reaction …